Offered by David Apollo
Genetic Diversity found in Mosquitos and Plasmodium causing Malaria
References
Note:
there are actually two genetically related reasons for false negative PfHRP2-specific rapid diagnostic test results. There could be:
Note the WHO malaria threat maps that detail where in the world drug resistance, insecticide resistance, and parasite gene deletions are occurring and hindering malaria control efforts:
http://apps.who.int/malaria/maps/threats/
References
Amoah, L. E., Abankwa, J., & Oppong, A. (2016).
Plasmodium falciparum histidine rich protein-2 diversity and the implications
for PfHRP 2: based malaria rapid diagnostic tests in Ghana. Malar J, 15.
https://doi.org/10.1186/s12936-016-1159-z
Baker, J., Ho, M.-F., Pelecanos, A., Gatton, M., Chen, N.,
Abdullah, S., ... Cheng, Q. (2010). Global sequence variation in the
histidine-rich proteins 2 and 3 of Plasmodium falciparum: implications for the
performance of malaria rapid diagnostic tests. Malaria Journal, 9(1),
129. https://doi.org/10.1186/1475-2875-9-129
Baker, J., McCarthy, J., Gatton, M., Kyle, D. E., Belizario,
V., Luchavez, J., ... Cheng, Q. (2005). Genetic Diversity of Plasmodium
falciparum Histidine - Rich Protein 2 (PfHRP2)
and Its Effect on the Performance of PfHRP2 - Based Rapid Diagnostic Tests. The Journal of Infectious
Diseases, 192(5), 870 - 877. https://doi.org/10.1086/432010
Berhane, A., Anderson, K., Mihreteab, S., Gresty, K., Rogier,
E., Mohamed, S., ... Cunningham, J. (2018). Major Threat to Malaria CControl
Programs by Plasmodium falciparum Lacking Histidine-Rich Protein 2,
Eritrea. Emerging Infectious Diseases, 24(3), 462 - 4700.
https://doi.org/10.3201/eid2403.171723
Cheng, Q., Gatton, M. L., Barnwell, J., Chiodini, P.,
McCarthy, J., Bell, D., & Cunningham, J. (2014). Plasmodium falciparum
parasites lacking histidine-rich protein 2 and 3: a review and recommendations
for accurate reporting. Malaria Journal, 13(1), 283.
https://doi.org/10.1186/1475-2875-13-283
Demographic and Health Surveys Program. (2018). MIS overview.
Retrieved February 19, 2018, from
https://dhsprogram.com/what-we-do/survey-types/mis.cfm
Kozycki, C. T., Umulisa, N., Rulisa, S., Mwikarago, E. I.,
Musabyimana, J. P., Habimana, J. P., ... Krogstad, D. J. (2017). False-negative
malaria rapid diagnostic tests in Rwanda: impact of Plasmodium falciparum
isolates lacking hrp2 and declining malaria transmission. Malaria Journal,
16(1), 123. https://doi.org/10.1186/s12936-017-1768-1
Parr, J. B., Verity, R., Doctor, S. M., Janko, M.,
Carey-Ewend, K., Turman, B. J., ... Meshnick, S. R. (2016). Pfhrp2-deleted
Plasmodium falciparum parasites in the Democratic Republic of Congo: A national
cross-sectional survey. Journal of Infectious Diseases, 216(1).
https://doi.org/10.1093/infdis/jiw538
Watson, O. J., Slater, H. C., Verity, R., Parr, J. B.,
Mwandagalirwa, M. K., Tshefu, A., ... Ghani, A. C. (2017). Modelling the drivers
of the spread of Plasmodium falciparum hrp2 gene deletions in sub-Saharan
Africa. eLife, 6. https://doi.org/10.7554/eLife.25008
World Health Organization. (2016). False-negative RDT results
and implications of new reports of P. falciparum histidine-rich protein 2/3
gene deletions. Retrieved Retrieved February 1, 2018, from https://www.finddx.org/wp-content/uploads/2016/06/WHO-information-note-false-neg-rdt-results-May2016.pdf
World Health Organization. (2016). World Malaria Report
2016. Retrieved Retrieved March 18, 2018, from
http://apps.who.int/iris/bitstream/10665/252038/1/9789241511711-eng.pdf
World Health Organization. (2017a). Map production: Global
malaria programme. Retrieved February 12, 2018, from
http://apps.who.int/malaria/maps/threats/
World Health Organization. (2017b). WHO-FIND malaria
evaluation programme. Retrieved February 10, 2018, from http://www.who.int/malaria/areas/diagnosis/rapid-diagnostic-tests/rdt-evaluation-programme/en/